. 2014 Oct 27;9(10):e107756. doi: 10.1371/journal.pone.0107756

Table 1. Characteristics of mouse studies used in meta-analysis and qualitative analysis.

Study	Intervention	Sample size	Mouse model	Duration of treatment (months)	Age (months)	Favored Group:	Quality assessment score (%)^F
						1. FD vs SFD
						2. NC vs SFD
1. Chan et al 2008A ^A	1. NC diet	1. n = 7^C	Normal (C57B/6)	1	9–12	1. SFD	62
	2. FD diet	2. n = 7^C				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 7^C
2. Chan et al 2008B ^A	1. NC diet	1. n = 7^C	ApoE −/−	1	9–12	1. SFD	62
	2. FD diet	2. n = 7^C				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 7^C
3. Chan et al 2008C ^A	1. NC diet	1. n = 7^C	ApoE2	1	9–12	1. SFD	62
	2. FD diet	2. n = 7^C				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 7^C
4. Chan et al 2008D ^A	1. NC diet	1. n = 7^C	ApoE3	1	9–12	1. FD	62
	2. FD diet	2. n = 7^C				2. NC
	3. SFD diet (100 mg/kg)	3. n = 7^C
5. Chan et al 2008E ^A	1. NC diet	1. n = 7^C	ApoE4	1	9–12	1. SFD	62
	2. FD diet	2. n = 7^C				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 7^C
6. Chan et al 2008F ^A	1. NC diet	1. n = 7^C	Healthy, Aged (C57B/6)	1	2–2.5 (years)	1. SFD	62
	2. FD diet	2. n = 7^C				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 7^C
7. Chan et al 2008G ^A	1. NC diet	1. n = 7^C	MTHFR +/+	1	9–12	1. SFD	62
	2. FD diet	2. n = 7^C				2. NC
	3. SFD diet (100 mg/kg)	3. n = 7^C
8. Chan et al 2008H ^A	1. NC diet	1. n = 7^C	MTHFR +/−	1	9–12	1. SFD	62
	2. FD diet	2. n = 7^C				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 7^C
9. Shea et al 2007A ^A	1. NC diet	1. n = 12	ApoE4	1 month SAM fortification for group 3 started 2 weeks after experiment started	9–12	1. SFD	66
	2. FD diet	2. n = 6				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 6
10. Shea et al 2007B ^A	1. NC diet	1. n = 16	Normal (C57B/6)	1 month SAM fortification for group 3 started 2 weeks after experiment started	9–12	1. No comparison	66
	2. No group	2. N/A				2. SFD
	3. SFD diet (100 mg/kg)	3. n = 8
11. Tchantchou et al 2004A ^A	1. NC diet	1. n = 11^D	ApoE−/−	1	9–12	1. FD	58
	2. FD diet	2. n = 11^D				2. NC
	3. SFD diet (80 mg/kg)	3. n = 11^D
12. Fuso et al 2012A ^B	1. NC diet	1. n = 10	TgCRND8	3	3+3 weeks	Not included for quantitative analysis^E	100
	2. FD diet	2. n = 10
	3. SFD diet (400 µg/mouse)	3. n = 9
13. Fuso et al 2012B ^B	1. NC diet	1. n = 8	129SV	3	3+3 weeks	Not included for quantitative analysis^E	100
	2. FD diet	2. n = 15
	3. SFD diet (400 µg/mouse)	3. n = 12

Y maze used to measure spatial memory outcome.

Morris Water Maze (MWM) used to measure spatial memory outcome.

Sample size reported in original article as 3–4 mice in 2 independent experiments.

Sample size reported as 3–4 mice/diet/experiment×2–4 experiments for a total of 6–16 mice per treatment group.

Data not included in quantitative analysis due to differences in measures, included in qualitative analysis for discussion.

Quality assessment conducted using the Gold Standard Publication Checklist by Hooijmans (2010); quality assessment scores re-scaled such that the study with the highest quality score was set at 100 (% scale).