Table 2. Cox proportional hazard models for all-cause mortality introducing achieved HbA1c, SBP, and LDL-C as post-index mean values.

	Patient number	Mortality rate (per 1000 person-years)	Model 1		Model 2
			Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
HbA1c (%)*
<6.0	444	41.7	1.37 (1.14–1.64)	<0.001	1.43 (1.19–1.71)	<0.001
6.0–7.0	2665	20.9	0.88 (0.79–0.99)	0.034	0.95 (0.85–1.07)	0.4
7.0–8.0	4187	14.3	0.68 (0.61–0.75)	<0.001	0.69 (0.62–0.77)	<0.001
8.0–9.0	2758	18.0	0.83 (0.74–0.93)	0.002	0.82 (0.73–0.92)	0.001
9.0–10.0	1408	17.2	0.98 (0.84–1.13)	0.8	0.91 (0.78–1.05)	0.20
≥10.0	1181	22.3	1.50 (1.30–1.74)	<0.001	1.44 (1.24–1.67)	<0.001
SBP (mmHg)*
<120	834	15.9	1.06 (0.86–1.32)	0.6	1.14 (0.92–1.42)	0.23
120–130	3182	18.9	1.06 (0.94–1.20)	0.33	1.10 (0.98–1.25)	0.12
130–140	4617	16.6	0.66 (0.60–0.72)	<0.001	0.80 (0.72–0.90)	<0.001
140–150	2692	18.8	0.84 (0.74–0.96)	0.009	0.85 (0.75–0.97)	0.014
150–160	941	21.6	1.14 (0.95–1.36)	0.17	1.06 (0.88–1.27)	0.6
≥160	377	20.1	1.15 (0.85–1.54)	0.4	1.10 (0.82–1.48)	0.5
LDL-C (mg/dL)*
<70	676	33.7	1.30 (1.11–1.53)	0.001	1.19 (1.01–1.40)	0.038
70–100	3604	19.6	0.80 (0.72–0.89)	<0.001	0.80 (0.72–0.89)	<0.001
100–130	6051	14.1	0.81 (0.72–0.90)	<0.001	0.68 (0.61–0.75)	<0.001
130–160	1806	19.5	0.94 (0.82–1.06)	0.31	1.00 (0.87–1.13)	0.9
≥160	506	31.9	1.56 (1.30–1.86)	<0.001	1.56 (1.30–1.86)	<0.001

The models used Cox proportional hazards regression analyses adjusted for potential confounders. The hazard ratios relative to the population mean were calculated.

*HbA1c, SBP, and LDL-C were calculated as the mean of any values recorded between the index date and death or censor.

Model 1 adjusted for age and sex.

Model 2 included the confounders in model 1, plus pre-existing myocardial infarction, congestive heart failure, stroke, malignant neoplasm, chronic kidney disease, use of insulin, any anti-hypertensive drug, any lipid-lowering drug, and antiplatelet.