Table 3. Cox proportional hazard models for all-cause mortality introducing achieved HbA1c, SBP, or LDL-C as updated, cumulative, yearly mean values.

	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
HbA1c (%)*	Model 1		Model 2
<6.0	1.21 (1.02–1.44)	0.033	1.27 (1.06–1.51)	0.008
6.0–7.0	0.86 (0.77–0.97)	0.011	0.93 (0.83–1.04)	0.21
7.0–8.0	0.76 (0.68–0.84)	<0.001	0.77 (0.69–0.85)	<0.001
8.0–9.0	0.94 (0.83–1.05)	0.25	0.92 (0.82–1.03)	0.16
9.0–10.0	1.04 (0.90–1.21)	0.6	0.98 (0.84–1.13)	0.7
≥10.0	1.30 (1.12–1.50)	0.001	1.23 (1.06–1.43)	0.006
SBP (mmHg)*	Model 3		Model 4
<120	0.92 (0.76–1.13)	0.4	0.98 (0.80–1.20)	0.8
120–130	1.02 (0.90–1.15)	0.8	1.06 (0.94–1.19)	0.4
130–140	0.96 (0.86–1.07)	0.4	0.93 (0.84–1.04)	0.23
140–150	0.98 (0.86–1.11)	0.7	0.95 (0.84–1.08)	0.4
150–160	1.10 (0.91–1.32)	0.32	1.06 (0.88–1.28)	0.5
≥160	1.04 (0.79–1.36)	0.8	1.03 (0.78–1.35)	0.9
LDL-C (mg/dL)*	Model 5		Model 6
<70	1.33 (1.14–1.56)	<0.001	1.26 (1.08–1.47)	0.004
70–100	0.87 (0.78–0.97)	0.009	0.85 (0.77–0.94)	0.002
100–130	0.75 (0.68–0.83)	<0.001	0.77 (0.70–0.85)	<0.001
130–160	0.84 (0.74–0.95)	0.007	0.87 (0.77–0.99)	0.034
≥160	1.37 (1.15–1.62)	<0.001	1.39 (1.17–1.66)	<0.001

The models used Cox proportional hazards regression analyses adjusted for potential confounders. The hazard ratios relative to the population mean were calculated.

*HbA1c, SBP, or LDL-C was introduced in an updated, cumulative, yearly mean value (with the last observation carried forward for missing data).

Model 1 adjusted for age, sex, mean SBP, and LDL-C.

Model 3 adjusted for age, sex, mean HbA1c, and LDL-C.

Model 5 adjusted for age, sex, mean HbA1c, and SBP.

Model 2,4,6 included the confounders in model 1,2,3, respectively, plus pre-existing myocardial infarction, congestive heart failure, stroke, malignant neoplasm, chronic kidney disease, use of insulin, any anti-hypertensive drug, any lipid-lowering drug, and antiplatelet.