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Chemical signaling schemas. (Panel A) Upstream stimulation by targeting ChR2 to either ON bipolar cells or the AII amacrine cell. In principle, this provides the most faithful pathway encoding, barring corruption by remodeling. (Panel B) Downstream stimulation by targeting ChR2 or DENAQ to ganglion cells. The entire ganglion cell stimulus-response domain is homogeneous, as we lack tools to differentially target and drive individual ganglion cells.
