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. 2014 Oct 27;9(10):e111006. doi: 10.1371/journal.pone.0111006

Figure 2. Model of arachidonic acid/eicosanoid metabolism.

Figure 2

The model has three branches. Through the first branch arachidonic acid (AA) forms leukotriene A4. In the second branch 15-HPETE and 15-HETE are derived from AA, while in the third branch AA forms prostaglandin D2. See the results section for a detailed description of the model inhibitory links. Phosphatidylcholine, PC; arachidonic acid, AA; phospholipase A2, PLA2; phosphorylated ERK, P-ERK; cyclooxygenase-1, also known as prostaglandin G/H synthase 1, PTGS1; protein kinase C delta, PKCD; signal transducer and activator of transcription 3, STAT3; arachidonate 15-lipoxygenase, ALOX15; arachidonate 5-lipoxygenase, ALOX5; arachidonate 5-lipoxygenase-activating protein, ALOX5AP; prostaglandin H2, PGH2; prostaglandin D2, PGD2; prostaglandin D2 synthase, PTGDS; 15-hydroxyeicosatetraenoic acid, 15-HETE; 5- and 15-hydroperoxyeicosatetraenoic acid, 5- and 15-HPETE; leukotriene A4, LTA4; glutathione peroxidase, GPX.