Table 2. Biological Activities of DM + CH + HG and DM + CH + HS Ternary Copolymers versus DM50CH50.
| MIC (μg/mL)d |
||||||||
|---|---|---|---|---|---|---|---|---|
| polymer | Mna | DPb | PDIc | E. coli | B. subtilis | S. aureus | E. faecium | HC10 (μg/mL)e |
| DM50CH50 | 4766 | 26 | 1.05 | 12.5 | ≤1.6 | 6.25 | 6.25 | 6.25 |
| DM50CH40HG10 | 4341 | 24 | 1.25 | 12.5 | 3.13 | 12.5 | 12.5 | 25–50 |
| DM50CH25HG25 | 5539 | 33 | 1.25 | 50 | 3.13 | 25 | 50 | 200 |
| DM50CH40HS10 | 5731 | 28 | 1.09 | 25 | 1.6 | 12.5 | 6.25 | 50 |
| DM50CH25HS25 | 7482 | 32 | 1.08 | 100 | 3.13 | 50 | 25 | 200 |
| DM40CH50HG10 | 4383 | 26 | 1.21 | 6.25 | 3.13 | 12.5 | 12.5 | 12.5 |
| DM40CH50HS10 | 5443 | 28 | 1.09 | 12.5 | 3.13 | 12.5 | 12.5 | 100 |
a
Number-average molecular weight.
b
Average degree of polymerization.
c
Polydispersity index based on GPC data obtained for polymers bearing Boc protecting groups on DM unit side chains and trityl protecting groups on HS unit side chains.
d
Minimum inhibitory concentration for bacterial growth.
e
Polymer concentration for 10% lysis of hRBCs.