Table 3. Biological Activities of Representative Binary versus Ternary Nylon-3 Copolymers Having the Same Hydrophobic:Cationic Molar Ratio and Varied Content of the Third (Hydrophilic) Subunit HG or HS.
| MIC (μg/mL)d |
||||||||
|---|---|---|---|---|---|---|---|---|
| polymer | Mna | DPb | PDIc | E. coli | B. subtilis | S. aureus | E. faecium | HC10 (μg/mL)e |
| DM50CH50 | 4766 | 26 | 1.05 | 12.5 | ≤1.6 | 6.25 | 6.25 | 6.25 |
| DM47.5CH47.5HG5 | 3558 | 20 | 1.20 | 12.5 | ≤1.6 | 12.5 | 12.5 | 400 |
| DM45CH45HG10 | 3174 | 18 | 1.24 | 25 | ≤1.6 | 12.5 | 25 | 400 |
| DM45CH45HS10 | 4943 | 25 | 1.12 | 25 | 1.6 | 12.5 | 12.5 | 200–400 |
| DM40CH40HS20 | 5539 | 26 | 1.05 | 50–100 | 3.13 | 25 | 50 | 200–400 |
a
Number-average molecular weight.
b
Average degree of polymerization.
c
Polydispersity index based on GPC data obtained for polymers bearing Boc protecting groups on DM unit side chains and trityl protecting groups on HS unit side chains.
d
Minimum inhibitory concentration for bacterial growth.
e
Polymer concentration for 10% lysis of hRBCs.