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. 2014 Sep 23;136(41):14413–14416. doi: 10.1021/ja508808v

Table 1. IC50 Values of Tested Compounds against HMLER and HMLERtax Cells.

compound HMLER IC50 (μM) HMLERtax IC50 (μM) selectivity for HMLERtaxa
1 11.20 ± 0.48 4.91 ± 0.86 2.31
2 14.58 ± 0.20 16.06 ± 4.12 0.91
3 82.80 ± 18.43 53.99 ± 2.45 1.53
salinomycin 0.49 ± 0.26 0.058 ± 0.01 8.45
abamectin 1.45 ± 0.18 0.64 ± 0.06 2.26
cisplatin 1.95 ± 0.40 2.06 ± 0.67 0.95
carboplatin 17.84 ± 0.58 18.19 ± 0.80 0.98
oxaliplatin 15.04 ± 0.41 26.95 ± 4.42 0.55
satraplatin 1.22 ± 0.06 2.87 ± 0.23 0.43
Pt(IV)-C2 39.09 ± 9.82 40.64 ± 9.91 0.96
Pt(IV)-C16 0.0254 ± 0.0016 0.1131 ± 0.0197 0.22
a

Selectivity = IC50 for HMLER/IC50 for HMLERtax. The values reported are an average of five independent determinations.