Table 1. IC50 Values of Tested Compounds against HMLER and HMLERtax Cells.
compound | HMLER IC50 (μM) | HMLERtax IC50 (μM) | selectivity for HMLERtax a |
---|---|---|---|
1 | 11.20 ± 0.48 | 4.91 ± 0.86 | 2.31 |
2 | 14.58 ± 0.20 | 16.06 ± 4.12 | 0.91 |
3 | 82.80 ± 18.43 | 53.99 ± 2.45 | 1.53 |
salinomycin | 0.49 ± 0.26 | 0.058 ± 0.01 | 8.45 |
abamectin | 1.45 ± 0.18 | 0.64 ± 0.06 | 2.26 |
cisplatin | 1.95 ± 0.40 | 2.06 ± 0.67 | 0.95 |
carboplatin | 17.84 ± 0.58 | 18.19 ± 0.80 | 0.98 |
oxaliplatin | 15.04 ± 0.41 | 26.95 ± 4.42 | 0.55 |
satraplatin | 1.22 ± 0.06 | 2.87 ± 0.23 | 0.43 |
Pt(IV)-C2 | 39.09 ± 9.82 | 40.64 ± 9.91 | 0.96 |
Pt(IV)-C16 | 0.0254 ± 0.0016 | 0.1131 ± 0.0197 | 0.22 |
Selectivity = IC50 for HMLER/IC50 for HMLERtax. The values reported are an average of five independent determinations.