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(a) Iobitridol chemical structure with a single amide proton group. (b) CEST spectra of 30 mM iobitridol solution at pH of 5.5 (solid line), 6.0 (dashed line), and 7.0 (dotted line). The reduction in MRI signal from bulk water signal upon selective irradiation at 5.6 ppm is pH sensitive (RF saturation power = 3 μT × 5 s, T = 310 K, Bo = 7 T). (c) Numerically solved pH-dependent chemical exchange rate for labile protons at 5.6 ppm.
