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Photocontrol of transcription factor FOXO3. (a) The construct of OptoNLS-FOXO3-mCherry has the OptoNLS inserted at the site of the native NLS. (b) OptoNLS-FOXO3-mCherry (left) is initially excluded from the nucleus but efficiently enters the nucleus after photorelease (right, 120 s illumination, mean nuclear signal fractions: 0.06 ± 0.03 and 0.64 ± 0.16, respectively).
