Table 1. Serpins used in this study.

Serpin	Systematicname	Main Targetproteases	Function	Reference
α1-Protease Inhibitor	SERPINA1	neutrophilelastase	Protection of tissue duringinflammation, deficiencyresults in emphysema	[15], [56]–[58]
α1-Antichymotrypsin	SERPINA3	CathepsinG, mast cell chymases	Deficiency may result inemphysema, possiblecontribution to Alzheimer	[15], [18], [59]–[61]
Angiotensinogen	SERPINA8	-	Non-inhibitory, reninsubstrate, release ofangiotensin I	[25], [62]
α2-Antiplasmin	SERPINF2	plasmin	Regulation of fibrinolysis	[19], [45]
Antithrombin III	SERPINC1	thrombin,FIXa, FXa	Most important inhibitorof the coagulation pathway	[21]–[24]

Given are the systematic serpin name, target proteases, and general function.