Figure 6. Fluorofenidone inhibits AKT activation in the diabetic kidneys of db/db mice.

AKT activation (phosphorylation of AKT at serine 473, p-AKT), total AKT, and GAPDH in individual groups were determined by western blot; typical results from the 5-week old animals are shown (A). Quantification of western blot results is expressed as fold change compared to that in db/m mice. The symbols * and # represent p<0.05 in comparison to db/m and the individual Ctrl mice, respectively (B). Three mice were used in individual groups.