Table 1. The kinetics of renal function in early stages of diabetic pathogenesis in db/db mice.

	db/m	db/db
	5 week n = 6	5 week n = 6	8 week n = 6	12 week n = 6
ACR(µg/mg)	0.13±0.03	0.56±0.17*	0.81±0.28*	1.04±0.44*
UAE (µg/24 h)	10.58±3.47	35.4±17.89	66.17±20.36*	91.91±32.15* a
BW(g)	17.86±1.04	23.35±4.29	37.25±5.55*	47.31±4.46*
GLU(mmol/L)	11.05±1.09	13.32±1.68	24.95±5.85*	25.93±8.24*

The indicated mice were 5, 8, and 12-weeks old; ACR: albumin/creatinine ratio; UAE: urinary albumin excretion determined by using 24 h (hour) urine collections; BW: body weight; GLU: glucose.

*p<0.05 vs. the db/m group; ^a p<0.05 the 5-week old mice.