Fig. 7.

In vivo antitumor effects of various treatments against tumors in tumor-bearing mice (n=4). (A) Tumor growth curves for tumor-bearing mice. (B) Changes in body weight during the treatments.

The tumor-bearing mice were intravenously injected with HBS used as a vehicle (control), free Dox, Dox–PEG, or AG73–Dox ([Dox]=2 mg/kg) when the tumor volume reached about 50 mm³ (5 days after tumor inoculation). The tumor volumes and the body weights of the tumor-bearing mice were monitored. Each value is presented as the average with SE. The arrows show the days of injection. Significant differences were found between the AG73–Dox and free Dox groups and are marked as ^⁎p<0.05.