Table 1.

Overlap between 835 HIF-1–dependent genes up-regulated in isp-1 mutants and the genes from published microarray data

Microarray data used in previous publications (reference)	No. of up-regulated genes	No. of overlapping genes	Representation factor	P value
isp-1(qm150) (43)	709	48	1.4	P < 0.01
isp-1(qm150) (17)	1,875	112	1.3	P < 0.01
P. aeruginosa (48)	196	43	4.6	P < 0.0001
P. aeruginosa (49)	303	52	3.6	P < 0.0001
P. luminescens (47)	659	51	1.6	P < 0.001
Microbacterium nematophilium (46)	67	6	1.9	P = 0.097
E. faecalis (47)	639	36	1.2	P = 0.162
Serratia marscens (47)	599	24	0.8	P = 0.226

The number of up-regulated genes indicates the genes whose expression is increased by isp-1(qm150) mutations or by exposure to indicated pathogenic bacteria. See Dataset S1 for the detailed gene lists. Representation factors larger than one indicate more overlap than expected numbers obtained from two independent groups. P values were calculated by exact hypergeometric probability.