Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustration of the NC-P-L replication complex. The unique orientation of the MuV P tetramer places both PNTD and PCTD at each end of the P tetramer. We hypothesize that PNTD and PCTD act together to induce changes in NC for viral RNA synthesis by vRdRp. The primary role of PCTD is to target the vRdRp to the NC. PNTD acts primarily to uncoil the MuV NC and allow vRdRp to gain access to the sequestered vRNA.
