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. 2014 Oct 6;111(42):15256–15260. doi: 10.1073/pnas.1413135111

Fig. 3.

Fig. 3.

Internal circadian organization changes under simulated food shortage conditions. (A) SCN PER2 protein expression profiles for WFF (red) and ad libitum (green) fed mice do not show a phase shift of the SCN rhythm. Liver (B) and adrenal (C) Per2 mRNA expression is phase advanced in the WFF compared with the ad libitum fed group. (D) The plasma corticosterone concentration profile is phase advanced in mice undergoing the WFF protocol. (E) PER2 protein expression in coronal SCN sections at external time 6 and 18 for WFF and control mice. (F) Timing of peak expression as displayed (A–D) for WFF and ad libitum fed mice. (Left) Peak time using highest average value per day. (Right) Peak time as derived by harmonic regression (CircWave) analysis.