Table 3.

Busulfan clearance by different weight metrics and body mass index–based weight category, mean±SD (range).

Clearance metric	Normal	Obese	Severely Obese	P-value**
All patients
N (%)	82 (44.3%)*	66 (35.7%)	37 (20.0%)
CL (mL/min)	183±86.8 (45–560)	217±110 (40–588)	200±102 (28–580)	0.1411
CL/ABW (mL/min/kg)	2.64±1.1 (0.6–6.5)	2.56±1.12 (0.5–6.1)	1.95±0.94 (0.2–4.8)	0.00097
CL/IBW (mL/min/kg)	2.82±1.17 (0.6–6.5)	3.27±1.49 (0.6–8.1)	3.09±1.78 (0.4–10.4)	0.25
CL/CBW (mL/min/kg)	2.76±1.14 (0.6–6.5)	3.04±1.34 (0.6–7.1)	2.61±1.33 (0.3–8.1)	0.2
<60 years
N (%)	68 (43.6%)	52 (33.3%)	36 (23.1%)
CL (mL/min)	169±65.2 (45–384)	200±103 (40–560)	199±103 (28–580)	0.22
CL/ABW (mL/min/kg)	2.52±0.98 (0.6–5.2)	2.39±1.06 (0.5–5.8)	1.92±0.93 (0.2–4.8)	0.0022
CL/IBW (mL/min/kg)	2.71±1.06 (0.6–5.5)	3.07±1.49 (0.6–8.1)	3.09±1.81 (0.4–10.4)	0.60
CL/CBW (mL/min/kg)	2.64±1.02 (0.6–5.2)	2.86±1.34 (0.6–7.1)	2.6±1.35 (0.3–8.1)	0.60
≥60 years
N (%)	14 (48.3%)	14 (48.3%)	1 (3.4%)
CL (mL/min)	248±137 (72–560)	283±113 (144–588)	213	0.53
CL/ABW (mL/min/kg)	3.25±1.46 (1.2–6.5)	3.22±1.16 (1.5–6.1)	3	0.94
CL/IBW (mL/min/kg)	3.33±1.55(1.2–6.5)	4.04±1.29 (1.5–7)	3	0.23
CL/CBW (mL/min/kg)	3.31±1.48 (1.2–6.5)	3.73±1.18 (1.5–6.7)	3	0.38

^*One patient had marginal low BMI and was placed in the normal cohort to allow testing across 3 categories.

^**By Kruskal-Wallis rank sum test

ABW, actual bodyweight; IBW, ideal bodyweight, CBW, corrected bodyweight (used to dose)