Fig. 3.
The PDE4 inhibitor Ro 20-1724 reduced ethanol intake (A) and preference (B) in the two-bottle choice paradigm in C57BL/6J mice. Mice were provided with an ethanol (9%) bottle and a water bottle for 3 d. Ro 20-1724 (10 mg/kg) was administered (i.p.) twice a day. Data shown are means ± SEM; n = 7; *** P < 0.001 vs. corresponding vehicle.