Fig. 4.

Rolipram did not change intake of sucrose, quinine, or water. (A) Intake of sucrose at the concentrations of 2% and 4%; (B) water intake while the sucrose solution was provided; (C) intake of quinine at the concentrations of 0.03 or 0.1 mM; (D) water intake while the quinine solution was provided. The sweet (sucrose) or bitter (quinine) taste was tested for 3 d for each concentration also using the two-bottle choice paradigm in C57BL/6J mice. Rolipram (0.5 mg/kg) or vehicle was injected twice daily. Both vehicle- and rolipram-treated mice preferred 2% and 4% sucrose, while they avoided 0.1 mM quinine; however, there was no difference between the two treatment groups (P > 0.05). Data shown are means ± SEM; n = 8 - 10.