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. 2014 Nov;144(5):469–486. doi: 10.1085/jgp.201411222

Figure 3.

Figure 3.

Sulfonylurea inhibition of Kir6.2/SUR1- and Kir6.2/SUR2A-containing channels. (A and B) Representative KATP currents (top) and concentration-response relationships (bottom) for glibenclamide inhibition of Kir6.2/SUR1 (A; n = 6) and Kir6.2/SUR2A (B; n = 6) channels. The lines are the best fit of Eq. 1 to the mean data: (A) IC50 = 2.8 nM, h = 0.93, a = 0.32; (B) IC50 = 13 nM, h = 0.94, a = 0.32. (C and D) KATP currents (top) and concentration-response relationships (bottom) for gliclazide block of Kir6.2/SUR1 (C; n = 6) and Kir6.2/SUR2A-YS (D; n = 5) channels. The lines are the best fit of Eq. 1 to the mean data: (C) IC50 = 72 nM, h = 1.2, a = 0.42; (D) IC50 = 1.3 µM, h = 1.1, a = 0.65. Mean ± SEM.