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. 2014 Nov;144(5):357–378. doi: 10.1085/jgp.201411229

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© 2014 Van Hook et al.

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Figure 6. — Model of ribbon replenishment. (A) The terminal was modeled as a three-dimensional rectangular lattice of vesicle sites separated by δ, the diameter of a single vesicle (δ = 45 nm). This space was populated with vesicles at a density of ρ = 2234 v/µm³ that move through the terminal with a diffusion coefficient D = 0.11 µm²/s. The terminal also contains a synaptic ribbon, which has 110 vesicle attachment sites. (B and C) Two simple variations of the model in which CaM acts to alter the vesicle attachment probability by acting on either vesicles themselves (B, red) or vesicle attachment sites on the ribbon (C, red).