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. 2014 Oct 23;2:154. doi: 10.1186/s40478-014-0154-2

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© Aouizerate et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Myopathological features in ASM (A, C, E, G) and DM (B, D, F, H). A: Myofiber injuries in ASM predominate in perifascicular areas (arrows) with the rounded atrophic appearance of regenerating myofibers; inflammatory infiltrates are mainly observed in perimysium and perifascicular endomysium and are associated with fragmentation of perimysium (asterisk). B: Perifascicular atrophy in DM characterized bymyofibers in peripheral regions of fascicles with a cross-sectional area substantially lower than in the rest of the fascicle(arrows). C: Myofiber NCAM expression (arrows) typically restricted to perifascular layers in ASM. D: In DM, NCAM-expressing myofibers are both perifascular (arrows) or grouped in foci (arrowheads). E, F: Diffuse myofiber reexpression of HLA-ABC in ASM (E) and DM (F), with marked perifascicular reinforcement in ASM (E). G, H: Macrophages in perimysium in the vicinity of fascicles (arrows) in ASM (G), and in perimysium (arrows) and perivascular areas (arrowhead) in DM (H). Frozen sections; hematoxylin-eosin (A, B) and immunoperoxidase technique for NCAM (C, D), HLA-ABC (E, F) and CD68 (G, H).