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. 2014 Oct 23;2:154. doi: 10.1186/s40478-014-0154-2

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© Aouizerate et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of myopathological lesions in DM (A, B) and ASM(C). A: Myosinolysis defined by the presence of punched-out vacuoles (arrows) or myofibrillar rarefaction areas, corresponding to foci of myosin filament proteolysis. B: Microinfarcts defined by numerous contiguous fibres within a fascicle, at the same stage of necrosis or regeneration. C: Perimysial fragmentation defined by focal clear areas (asterisk) and spumous appearance of adjacent areas (arrowhead). D: Percentages of cases with presence of the lesion (perimysial fragmentation, microinfarcts, vacuoles, and perifascicular atrophy) in ASM and DM. (*) indicates p < 0.05.Frozen sections (A-C); hematoxylin-eosin (A, B) and Masson trichrome (C).