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. 2014 Oct 23;2:154. doi: 10.1186/s40478-014-0154-2

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© Aouizerate et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CD8+ T-cell infiltration and myofiber HLA-DR expression. A, B: Comparison of CD8+ T-cells infiltration and myofiber HLA-DR expression in a same case of ASM. CD8+ T-cells (arrows) are detected in perifascicular endomysium and adjacent perimysium (A), in the areas corresponding to those of the strongest myofiber HLA-DR expression (B). Frozen section; immunoperoxidase technique for CD8 and HLA-DR. C: Percentage of patients with a CD8+ score equal to 1 or 2, in ASM and DM; (*) indicates p < 0.05. D: Percentage of HLA-DR-positive myofibers according to the degree of CD8+ T-cell infiltration. Comparison was done between patients with a CD8+ score null and patients with score equal to 1 or 2, ASM and DM patients having been pooled.