Table 3.
Genotype frequencies of selected SNPs in controls and children with bronchospasm a
| Observed | Expected | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene and polymorphic alleles | Control group (n = 119) | Children with wheezing (n = 119) | Control group (n = 119) | Children with wheezing (n = 119) | HWE, χ 2 controls | HWE, χ 2 wheezing | |||||||
| N | % | N | % | N | % | N | % | p-value | p-value | OR b | 95% CI | p-value c | |
| IL8-rs4073 | |||||||||||||
| A | 28 | 23.7 | 21 | 17.8 | 22.5 | 19.0 | 20.8 | 17.6 | 1.00 | (Reference) | - | ||
| A/T | 47 | 39.8 | 57 | 48.3 | 58.0 | 49.2 | 57.5 | 48.7 | 2.50 | (1.15-5.44) | 0.02 | ||
| T | 43 | 36.4 | 40 | 33.9 | 37.5 | 31.8 | 39.8 | 33.7 | 0.04 | 0.93 | 1.57 | (0.71-3.45) | 0.27 |
| VEGFA-rs833058 | |||||||||||||
| C | 32 | 27.1 | 22 | 18.5 | 32.6 | 27.6 | 28.3 | 23.8 | 1.00 | (Reference) | - | ||
| C/T | 60 | 50.9 | 72 | 60.5 | 58.8 | 49.9 | 59.5 | 50.0 | 2.22 | (1.09-4.55) | 0.03 | ||
| T | 26 | 22.0 | 25 | 21.0 | 26.6 | 22.5 | 31.3 | 26.3 | 0.83 | 0.02 | 1.96 | (0.83-4.65) | 0.13 |
| MBL2-rs1800450 | |||||||||||||
| C | 87 | 73.7 | 76 | 63.9 | 87.3 | 74.0 | 77.4 | 65.1 | 1.00 | (Reference) | - | ||
| C/T | 29 | 24.6 | 40 | 33.6 | 28.4 | 24.1 | 37.1 | 31.2 | 1.90 | (1.01-3.58) | 0.05 | ||
| T | 2 | 1.7 | 3 | 2.5 | 2.3 | 2.0 | 4.4 | 3.7 | 0.81 | 0.40 | 1.03 | (0.15-7.23) | 0.97 |
| IKBKB-rs3747811 | |||||||||||||
| A | 36 | 31.3 | 20 | 17.1 | 28.3 | 24.6 | 24.5 | 20.9 | 1.00 | (Reference) | - | ||
| A/T | 42 | 36.5 | 67 | 57.3 | 57.5 | 50.0 | 58.1 | 49.6 | 3.26 | (1.55-6.85) | 0.0018 | ||
| T | 37 | 32.2 | 30 | 25.6 | 29.3 | 25.4 | 34.5 | 29.5 | 0.004 | 0.10 | 2.01 | (0.89-4.53) | 0.09 |
| CTLA4-rs3087243 | |||||||||||||
| A | 25 | 21.2 | 35 | 29.7 | 32.1 | 27.2 | 35.8 | 30.3 | 1.00 | (Reference) | - | ||
| A/G | 73 | 61.9 | 60 | 50.9 | 58.9 | 49.9 | 58.4 | 49.5 | 0.50 | (0.25-0.99) | 0.05 | ||
| G | 20 | 17.0 | 23 | 19.5 | 27.1 | 22.9 | 23.8 | 20.2 | 0.009 | 0.76 | 0.65 | (0.27-1.56) | 0.34 |
| NFKBIB-rs3136641 | |||||||||||||
| C | 64 | 54.2 | 72 | 61.0 | 59.8 | 50.7 | 71.0 | 60.1 | 1.00 | (Reference) | - | ||
| C/T | 40 | 33.9 | 39 | 33.1 | 48.4 | 41.0 | 41.1 | 34.8 | 0.90 | (0.49-1.66) | 0.73 | ||
| T | 14 | 11.9 | 7 | 5.9 | 9.8 | 8.3 | 6.0 | 5.0 | 0.06 | 0.58 | 0.33 | (0.11-0.94) | 0.04 |
aThe sums may not add up to the total because of a few missing values; bOdds ratios adjusted for age (< / ≥ 2 years). cp-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.
HWE Hardy-Weinberg equilibrium, NE Not estimable.