Table 2.
Predictors for MACCEs
| Univariable analysis | Adjusted model 1 * | Adjusted model 2 † | Adjusted model 3 ‡ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
| Total number of RBCs transfusion | 1.04 | 1.03-1.05 | <0.001 | 1.03 | 1.02-1.04 | <0.001 | 1.03 | 1.02-1.04 | <0.001 | 1.03 | 1.02-1.04 | <0.001 |
| Mean RBCs age | 0.97 | 0.94-1.00 | 0.053 | 0.98 | 0.95-1.01 | 0.248 | ||||||
| Maximum RBCs age | 1.01 | 0.99-1.04 | 0.368 | 1.001 | 0.97-1.03 | 0.948 | ||||||
| Any RBCs unit >14 days | 1.01 | 0.75-1.35 | 0.957 | 0.89 | 0.65-1.24 | 0.504 | ||||||
| Age | 1.03 | 1.01-1.04 | 0.005 | |||||||||
| Male | 0.94 | 0.68-1.28 | 0.679 | |||||||||
| Body mass index (kg m-2) | 0.99 | 0.95-1.04 | 0.652 | |||||||||
| Smoking | 0.92 | 0.69-1.23 | 0.563 | |||||||||
| Diabetes mellitus | 0.9 | 0.67-1.21 | 0.493 | |||||||||
| Hypertension | 1.4 | 0.99-1.98 | 0.059 | |||||||||
| Dyslipidemia | 1.13 | 0.81-1.58 | 0.47 | |||||||||
| Previous myocardial infarction | 1.05 | 0.62-1.78 | 0.852 | |||||||||
| Previous stroke | 1.27 | 0.87-1.88 | 0.221 | |||||||||
| Acute renal failure | 1.97 | 0.73-5.33 | 0.179 | |||||||||
| Chronic renal failure | 1.6 | 1.1-2.34 | 0.015 | |||||||||
| LV dysfunction (EF < 35%) | 1.46 | 0.99-2.14 | 0.053 | |||||||||
| COPD | 2.83 | 1.05-7.62 | 0.04 | |||||||||
| Previous cardiac surgery | 1.24 | 0.58-2.65 | 0.572 | |||||||||
| Perioperative IABP insertion | 1.77 | 1.30-2.40 | <0.001 | |||||||||
| Emergent operation | 1.59 | 1.13-2.24 | 0.008 | |||||||||
| Duration of surgery (min) | 1 | 1.00-1.00 | 0.093 | |||||||||
| preoperative statin use | 0.88 | 0.65-1.17 | 0.35 | |||||||||
| postoperative statin use | 0.49 | 0.32-0.75 | 0.001 | 0.56 | 0.37-0.85 | 0.007 | 0.56 | 0.37-0.86 | 0.007 | 0.56 | 0.37-0.85 | 0.006 |
| anesthetics (sevoflurane vs. propofol) | 0.82 | 0.59-1.15 | 0.26 | |||||||||
| lowest intraoperative heart rate | 0.99 | 0.98-1.01 | 0.828 | |||||||||
| lowest intraoperative mean arterial pressure | 1 | 0.99-1.01 | 0.87 | |||||||||
| lowest intraoperative mixed venous saturation | 1.02 | 0.99-1.04 | 0.24 | |||||||||
| lowest intraoperative cardiac index | 0.8 | 0.48-1.35 | 0.4 | |||||||||
| lowest perioperative hematocrit | 0.97 | 0.92-1.01 | 0.129 | |||||||||
*Adjusted model 1 was constructed including the mean RBCs age as a covariate.
†Adjusted model 2 was constructed including the oldest RBCs age as a covariate.
‡Adjusted model 3 was constructed including the ‘any RBCs unit >14 days’ as a covariate.
MACCE, major adverse cardiovascular and cerebral event; RBC, red blood cell; LV, left ventricle; EF, ejection fraction; COPD, chronic obstructive pulmonary disease; IABP, intra-aortic balloon pump.