Table 2.

Functional classification of changed miRNAs in IA tissues and their target genes

Biological processes/disorders	Changed miRNAs	Corresponding target genes
Programmed cell death	miR-29b, let-7a, miR-125a-5p, miR-199b-5p, miR-1, miR-30e*, miR-30c, miR-338-3p, miR-133a, miR-101, miR-26a, miR-362-3p, miR-362-5p, miR-330-3p, miR-296-5p, miR-139-5p, miR-103, miR-218	TNFRSF10B, TP53, BAK1, CASP6, CASP7, BCL2, CASP3, CASP9, MAP2K7, PTEN, BAX, AKT2, MAP2K4, MAPK1, MAPK3, PIK3R1, BNIP3L, BECN1
Extracellular matrix organization	miR-1, miR-30e*, miR-30c, miR-133a, let-7a, miR-199b-5p, miR-29b, miR-218	SERPINB5, CTGF, COL5A3, COL1A2, COL3A1, COL1A1, TGFBR1, TGFB3, SMAD3, MMP1, COL15A1, COL4A1, COL4A2, COL5A2, FBN1, SPARC
Response to oxidative stress	miR-133a, miR-30c, miR-199b-5p, miR-125a-5p, miR-1, let-7a, miR-101, miR-338-3p, miR-29b, miR-218, miR-26a, miR-296-5p, miR-139-5p	SIRT1, TXN2, HIF1A, GSS, SOD2, HMOX1, FOXO1,
TGF-beta signaling pathway	miR-125a-5p, miR-29b, miR-30c, miR-26a, miR-30e*, miR-1, let-7a, miR-218, miR-133a, miR-296-5p, miR-338-3p, miR-362-3p	ID2, ID1, ID3, ACVR2A, ACVR1, SMAD5, SMAD1, BMPR1B, BMPR2, TGFBR1, TGFBR2, SMAD4, TGFB3, SMAD3
Smooth muscle cell proliferation	miR-29b, miR-125a-5p, miR-1, let-7a, miR-101, miR-26a, miR-30c	KLF4, ID2, IGFBP3, PPARG, NOTCH3, IGF1, VEGFA, PTK2, JUN
Aortic dissection	miR-29b, miR-218, let-7a, miR-26a	COL3A1, COL1A1, TGFBR1, TGFBR2, SMAD3, COL5A2, FBN1

The target genes listed are all experimentally validated and published in the literature.