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. 2014 Oct 2;15(10):481. doi: 10.1186/s13059-014-0481-4

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© Bayne et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Csn1 and Csn2 affect heterochromatin integrity independently of RNAi. (A) cen1:ade6 ⁺ silencing assay. Equivalent cell numbers of the indicated strains were spotted in serial dilutions on non-selective plates (N/S), or plates containing 10ug/ml adenine (LOW ADE) or no adenine (-ADE). (B) Assay for silencing at the silent mating-type locus (mat3-M:ura4 ⁺). Plates are non-selective (N/S), lacking uracil (-URA) or supplemented with FOA (+FOA). (C) ChIP analysis of H3K9me2 levels at centromeric outer repeats (cen-dg) or the silent mating-type locus (mat) relative to act1 ⁺, normalised to wild-type. (D) Northern analysis of pericentromeric siRNAs. snoRNA58 (snR58) is a loading control.