Table 1.

Leakage of cerebral microvessels to exogenous and endogenous plasma tracers^a in c-mag_B8//agrn^−/− mice depending on gender and age (BBB blood-brain barrier)

Tracer	Number of mice with BBB leakage/total mice analyzed	Number of mice with BBB leakage at <6 weeks of age	Number of mice with BBB leakage at 7–21 weeks of age	Number of males with BBB leakage/total males	Number of females with BBB leakage/total females
Exogenous fluorophore-conjugated 3-kDa and 10-kDa Dextransa	3/23	0/2	3/21	3/11	0/12
Endogenous IgG (150–170 kDa) and fibronectin (340 kDa)a	7/23	2b/2	5/21	4/11	3/12

^aLeakage of tracers was determined by immunofluorescence staining and analysis of brain cryosections and was defined by the detection of the tracers beyond the laminin-positive vascular basement membranes of brain microvessels

^bExclusive leakage of murine IgG