APPENDIX 2.
Characteristics of Patients with Kernicterus
| B/A | TSB | Max. BIND | 3 mo AABR | Hct. | Cause of Jaundice | Adm weight, g | Adm Age, d | Comments | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 8.6 | 29.1 | 9 | ND | ND | Unknown | 2250 | 5.3 | DIED; pH 7.2 HCO3 15 Direct Bil. 5.6 |
| 2 | 8.6 | 34.2 | 9 | RR | 33.7 | Hemolysis O-A | 2800 | 5.5 | Dystonia at 3 mo |
| 3 | 9.0 | 37 | 7 | ND | 44.0 | Rh incompatibility | 2250 | 4 | DIED; Suspected sepsis |
| 4 | 9.1 | 31 | 8 | RR | 39.7 | Rh incomp. DAT neg. | 2800 | 5.8 | Severe ABE at admission; Klebsiella sepsis post-exchange |
| 5 | 9.6 | 41.2 | 9 | ND | 29.2 | Hemolysisa | 3100 | 3.8 | DIED; pH 6.97; apnea, seizures |
| 6 | 9.6 | 37.6 | 8 | ND | 38.8 | O-A incomp. | 2100 | 7.2 | Suspected sepsis |
| 7 | 9.7 | 32 | 4 | PR | 53.7 | Unknown | 3000 | 7.6 | Mild kernicterus 3 mo |
| 8 | 10.2 | 31.7 | 9 | RR | 37.0 | G6PD deficient | 3200 | 6.5 | No hemolysis, kernicterus at 3 mo |
| 9 | 10.3 | 28.9 | 9 | ND | 24.8 | Hemolysis Rh | 2250 | 4 | DIED; Suspected sepsis; pH 7.17b |
| 10 | 10.4 | 31.1 | 5 | RR | 47.3 | O-A incomp. | 1840 | 3 | 34.5 wks SGA, high reticulocyte count, Mild kernicterus |
| 11 | 10.5 | 43 | 8 | ND | 35.0 | Unknown | 2750 | 3.8 | DIED; 2 exchange transfusions. |
| 12 | 10.5 | 38.7 | 9 | ND | 29.4 | Hemolysisa | 2900 | 2 | Suspected sepsis |
| 13 | 10.6 | 35 | 8 | ND | 34.0 | Hemolysis O-A | 2500 | 3.4 | DIED; Pseudomonas sepsis; pH 7.10b |
| 14 | 10.8 | 40.02 | 8 | ND | 48.4 | Rh, moderate G6PD | 2750 | 4.5 | Direct bilirubin 10.8 with no hemolysis |
| 15 | 11.3 | 39.7 | 7 | RR | 41.9 | G6PD & O-A incomp. | 2030 | 13 | Late admission, kernicterus at 3 mo |
| 16 | 11.4 | 36.6 | 9 | ND | 45.4 | Unknown | 2250 | 8.1 | pH 7.23 |
| 17 | 11.5 | 42.5 | 9 | ND | 31.1 | Hemolysis O-B | 3200 | 3.8 | DIED; Suspected sepsis; seizures |
| 18 | 11.5 | 36.7 | 6 | RR | 42.5 | O-B incomp. | 2250 | 7.7 | Kernicterus at 3 mo |
| 19 | 11.8 | 43.6 | 6 | RR | 37.0 | O-A incomp. | 2970 | 5.9 | Kernicterus at 3 mo |
| 20 | 12.1 | 35.2 | 9 | ND | 42.9 | Unknown | 2000 | 5.8 | DIED; rapid deterioration after second exchangeb |
| 21 | 12.4 | 37 | 7 | RR | 30.0 | Hemolysis O-B | 2400 | 5 | 35 wk GA; hypertonic with head lag 3 mo |
| 22 | 12.6 | 39 | 9 | ND | 37.2 | O-A incomp. | 2300 | 4.7 | Suspected sepsisb |
| 23 | 12.6 | 44.2 | 8 | RR | 50.9 | Unknown | 2400 | 5.4 | Suspected sepsis; pH 7.33 kernicterus at 3 mo |
| 24 | 12.8 | 39.7 | 8 | ND | 31.4 | Hemolysis O-A | 2760 | 9.8 | DIED; Suspected sepsis; respiratory acidosis; apnea, seizures |
| 25 | 12.8 | 38.5 | 8 | RR | 37.0 | O-A incomp. | 3150 | 2.3 | Sustained high TSB; kernicterus at 3 mo |
| 26 | 13.7 | 47.9 | 7 | RR | 21.7 | Hemolysis G6PD def, | 2800 | 4.9 | Suspected sepsis; pH 7.30 |
| 27 | 14.0 | 36.5 | 7 | RR | 25.7 | Hemolysis Rh | 4000 | 4.2 | Deterioration after second exchangeb |
| 28 | 14.9 | 46.2 | 9 | ND | 49.0 | Unknown | 2140 | 6.2 | RR AABR and abnormal neurologically at discharge no FU |
| 29 | 15.1 | 40.7 | 7 | ND | ND | O-A incomp. | 3000 | 4 | DIED; classic kernicterus, seizures |
| 30 | 15.1 | 48.3 | 8 | RR | 38.1 | O-B incomp. | 2930 | 13 | Late admission; Na 157, kernicterus at 3 mo |
| 31 | 15.6 | 42.01 | 8 | RR | 31.7 | Hemolysis Rh | 2450 | 2.2 | Direct bilirubin 16, kernicterus at 3 mo |
| 32 | 17.8 | 32 | 9 | ND | 27.9 | Hemolysis O-A | 2440 | 4.3 | DIED; Suspected sepsis; pH 7.13 |
| 33 | 19.2 | 47.9 | 7 | ND | 41.5 | O-B & Rh incomp. | 2620 | 2.6 | DIED; deteriorated postexchangeb |
| 34 | 20.0 | 44.1 | 9 | ND | 31.9 | Hemolysisa | 2850 | 4.1 | DIED; pH 7.22 respiratory acidosis |
| 35 | 21.0 | 61.03 | 7 | RR | 27.4 | Hemolysis O-A | 2900 | 5.1 | Direct bilirubin 27.7; kernicterus at 3 mo |
Ranked by increasing B/A ratio. Adm: admission Hct; hematocrit; DAT, direct antiglobulin test; incomp, blood type incompatibility without evident hemolysis. Max, maximum; ND: not done. PR: Pass refer, FU: follow up
a
Unknown cause for hemolysis.
b
Onset of kernicterus or worsening postexchange transfusion.