Table 1.

Kinetics of transcription and splicing under different experimental conditions

DOI: http://dx.doi.org/10.7554/eLife.03939.019

	Elongation rate (kb/min)	Mean 3' end dwell time (sec)	Splicing time (sec)	Pre-release fraction (%)
Control	2.60 ± 0.16	116.1 ± 5.8	267 ± 9	15.9 ± 3.2
SSA+	2.41 ± 0.26	126.7 ± 5.7	485 ± 62 **	3.5 ± 2.4 **
CPT+	1.44 ± 0.09 **	111.0 ± 10.3	251 ± 10	24.9 ± 6.9
U2AF1 (wt)	2.24 ± 0.27	120.7 ± 4.9	280 ± 8	16.6 ± 3.3
U2AF1-S34F	2.64 ± 0.11	166.0 ± 7.0 **	694 ± 176 *	2.1 ± 2.6 **

The table shows result of fits with model II.4 (‘Materials and methods’ and Supplementary file 2). Pre-release fraction is deduced from the 3 other parameters. Errors are propagated SEM from correlation functions. * p-value<0.05, ** p-value<0.005 (two-sided z-test vs control).