Table 2. Distribution of CAD Risk Factors by MCP-1 Quartile.
| MCP-1 serum concentration quartiles (pg/ml) | p* | R | P* | ||||
|---|---|---|---|---|---|---|---|
| 1 (<38.3) | 2 (38.3 to 51.2) | 3 (51.2 to 66.8) | 4 (>66.8) | ||||
| Participants, n | 695 | 686 | 665 | 717 | - | - | - |
| Age, years | 65.2 (50.0 to 75.2) | 65.1 (49.5 to 75.1 | 65.4 (50.6 to 75.4) | 65.6 (51.2 to 75.4) | 0.195 | 0.027 | 0.158 |
| Women, n (%) | 264 (38) | 258 (38) | 240 (36) | 257 (36) | 0.331 | - | - |
| Body mass index, kg/m2 | 26.4 (21.4 to 32.8) | 26.5 (21.2 to 32.9) | 26.7 (21.3 to 33.3) | 26.8 (21.7 to 33.4) | 0.016 | 0.053 | 0.005 |
| Waist circumference, cm | 91 (71 to 110) | 92 (73 to 111) | 93 (74 to 112) | 93 (75 to 113 | <0.001 | 0.080 | <0.001 |
| Cigarette smoking, n (%) | 64 (9) | 74 (11) | 73 (11) | 88 (12) | 0.073 | - | - |
| Diabetes mellitus, n (%) | 19 (3) | 26 (4) | 27 (4) | 19 (3) | 0.337 | - | - |
| Systolic blood pressure, mmHg | 139 (111 to 174) | 140 (110 to 174) | 141 (112 to 175) | 142 (115 to 175) | 0.017 | 0.045 | 0.018 |
| Diastolic blood pressure, mmHg | 83 (65 to 104) | 84 (67 to 104) | 85 (66 to 105) | 85 (68 to 105) | 0.079 | 0.041 | 0.033 |
| Total cholesterol, mmol/l | 6.30 (4.5 to 8.3) | 6.3 (4.6 to 8.4) | 6.3 (4.7 to 8.3) | 6.4 (4.6 to 8.4) | 0.151 | 0.021 | 0.268 |
| LDL-cholesterol, mmol/l | 4.2 (2.6 to 5.9) | 4.1 (2.6 to 6.0) | 4.2 (2.7 to 6.0) | 4.2 (2.6 to 5.9) | 0.550 | 0.007 | 0.707 |
| HDL-cholesterol, mmol/l | 1.33 (0.80 to 2.10) | 1.35 (0.80 to 2.10) | 1.34 (0.80 to 2.00) | 1.31 (0.80 to 2.10) | 0.267 | −0.31 | 0.105 |
| Triglycerides, mmol/l | 1.6 (1.1 to 2.2) | 1.7 (1.2 to 2.3) | 1.7 (1.2 to 2.4) | 1.8 (1.3 to 2.4) | <0.001 | 0.087 | <0.001 |
| C-reactive protein, mg/l | 1.8 (0.8 to 3.7) | 1.5 (0.7 to 3.9) | 1.7 (0.8 to 3.9) | 1.7 (0.8 to 3.6) | 0.994 | 0.002 | 0.933 |
Data are presented as mean with the 95% confidence interval or number (percentage). Quartiles are based on values in control subjects. Triglycerides and CRP are presented as median with the 25th to 75th percentile and log transformed for the p-value calculations. P = p-value for linearity between MCP-1 serum concentration quartiles and risk factor levels; R = Pearson or Spearmans correlation between log-transformed MCP-1 serum concentration and risk factors, and the corresponding p-value.
†
(P). MCP-1 = Monocyte chemoattractant protein-1; LDL = low-density lipoprotein; HDL = high-density lipoprotein.