Table 3. Odds Ratios for Future CAD Events by MCP-1 Quartile and for MCP-1 as Continuous Variable.

	MCP-1 quartiles
	1	2	3	4	P*	Ln(MCP-1)†	P‡
MCP-1 levels (pg/ml)	< 38.3	38.3 to 51.2	51.2 to 66.8	> 66.8	-	-	-
Total no. of patients	695	686	665	717	-	-	-
Cardiovascular events, n (%)	251 (36.1)	241 (35.1)	220 (33.1)	273 (33.1)	-	-	-
Model 1	1	0.95 (0.76 to 1.20)	0.86 (0.68 to 1.09)	1.08 (0.86 to 1.36)	0.246	1.05 (0.87 to 1.27)	0.624
Model 2	1	0.91 (0.71 to 1.16)	0.81 (0.63 to 1.05)	0.96 (0.75 to 1.24)	0.368	0.94 (0.76 to 1.15)	0.524
Model 3	1	0.89 (0.70 to 1.13)	0.79 (0.62 to 1.00)	0.96 (0.75 to 1.22)	0.209	0.96 (0.79 to 1.17)	0.658

Odds ratios and corresponding 95% confidence intervals calculated by conditional logistic regression, taking into account matching for age, gender, and enrollment time, per MCP-1 quartile. CRP, triglycerides and MCP-1 were log-transformed before analysis. Model 1: unadjusted. Model 2: Adjusted for body mass index, smoking status, systolic blood pressure, LDL-cholesterol, HDL-cholesterol and CRP. Model 3: adjustment for the FRS.

^*P = p value for the association between MCP-1 quartiles and CAD risk.

^†P = Odds ratios and corresponding 95% confidence intervals calculated by conditional logistic regression, taking into account matching for age, gender and enrollment time, for MCP-1 as continuous variable.

^‡P = p value corresponding to Ln(MCP-1). MCP-1 = Monocyte chemoattractant protein-1; LDL = low-density lipoprotein; HDL = high-density lipoprotein; FRS = Framingham Risk Score.