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. Author manuscript; available in PMC: 2014 Oct 28.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Apr 18;33(9):2261–2266. doi: 10.1161/ATVBAHA.112.301120

Table 2. Risk for cardiovascular endpoints by genetic risk score.

Top versus middle 20%
Trait HR (95 % CI)* P-value Top 20% of GRS (95 % CI) Top 10% of GRS (95 % CI) Top 5% of GRS (95 % CI) N events N
CHD 1.27 ( 1.20 , 1.35 ) 1.2×10−14 1.71 ( 1.42 , 2.06 ) 2.07 ( 1.68 , 2.56 ) 2.12 ( 1.62 , 2.77 ) 1093 24124
ACS 1.27 ( 1.18 , 1.37 ) 3.1×10−10 1.57 ( 1.25 , 1.97 ) 1.84 ( 1.42 , 2.40 ) 2.00 ( 1.43 , 2.79 ) 731 24124
CVD 1.18 ( 1.12 , 1.24 ) 3.2×10−10 1.59 ( 1.36 , 1.86 ) 1.87 ( 1.56 , 2.24 ) 1.72 ( 1.35 , 2.18 ) 1552 24124
*

per SD of GRS. Cox regression models were adjusted for sex, total cholesterol, high-density lipoprotein (HDL) cholesterol, body-mass index, systolic blood pressure, antihypertensive treatment, smoking and type 2 diabetes; age was used as the timescale.

Abbreviations: CHD, coronary heart disease; ACS, acute coronary syndrome; CVD, cardiovascular disease; GRS, genetic risk score; HR, Hazard ratio; CI, confidence interval; N, number of individuals