. Author manuscript; available in PMC: 2014 Oct 28.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Apr 18;33(9):2261–2266. doi: 10.1161/ATVBAHA.112.301120

Table 3. Reclassification of individuals in four risk categories after addition of genetic risk score (GRS) to a model with traditional risk factors and family history^*.

Model without GRS			Model with GRS

		0-5%	5-10%	10-20%	>20%	NRI	Clinical NRI

0-5%	Events	79	15	0	0	Events: 0.04 (P=0.03)	Events: 0.15 (P=4.6×10⁻⁴)
						Events: 0.04 (P=0.03)
	Nonevents	7820	199	0	0

	All	7899	214	0	0	Nonevents: 0.01 (P-0.002)	Nonevents: 0.11 (P=3.3×10⁻¹²)

5-10%	Events	16	94	21	0	All: 0.05 (P=0.01)

	Nonevents	249	1080	173	0

	All	265	1174	194	0		All: 0.27 (P=1.1×10⁻⁸)

10-20%	Events	0	22	122	52

	Nonevents	0	206	745	87

	All	0	228	867	139

>20%	Events	0	0	22	186

	Nonevents	0	0	105	377

	All	0	0	127	563

Traditional risk factors include sex, total cholesterol, high-density lipiprotein (HDL) cholesterol, body-mass index, systolic blood pressure, blood pressure treatment, smoking and type 2 diabetes; age was used as the timescale in the Cox proportional hazards model. Abbreviations: NRI, net reclassification improvement

Table 3. Reclassification of individuals in four risk categories after addition of genetic risk score (GRS) to a model with traditional risk factors and family history*.

Table 3. Reclassification of individuals in four risk categories after addition of genetic risk score (GRS) to a model with traditional risk factors and family history^*.