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. 2014 Oct 17;12(10):5222–5239. doi: 10.3390/md12105222

Figure 4.

Figure 4

Cell cycle analysis of MDA-MB-231 cells treated with bioactive ascidian extracts. MDA-MB-231 cells were treated with the indicated bioactive ascidian extracts for 24 h and DNA content was measured by flow cytometry and quantified with ModFit LT 3.3 software. As control, cells were treated with DMSO (0.1%). Only the results of the extracts that arrested the breast cancer cells are shown below. (A) Cell cycle distribution of cells in G0/G1, S and G2/M phase of the cell cycle (mean ± SD, n = 3). Statistical information can be found in Supplementary Data (Supplementary Table S1); (B) Dead cells with hypodiploid DNA content (subG1) (mean ± SD, n = 3). Statistically significant results (p < 0.05) are highlighted with an asterisk.