Table 2.
Comparison of renal phenotype in diabetic eNOS −/− mice.
| Phenotype | Models | |||
|---|---|---|---|---|
| High-dose STZ (C57BL/6J) |
Low-dose STZ (C57BL/6J) |
Akita (C57BL/6J × 129S6/SvEv F1) | db/db (C57BLKS/J) |
|
| Albuminuria | ||||
| Vs. DM WT mice | 19.2 (fold increase) | 1.8–8.7 | 2.5 | 5.3–5.7 |
| Vs. non-DM WT mice | 43.1 | 2.0–30 | 16 | 34.9–37.5 |
| GFR∗ | ↓↓ | ↓ | ↑↑ | ↓↓ |
| Tubulointerstitial lesion∗ | ++ | + | decreased | ++ |
| Oxidative stress∗ | ? | → | ↓↓ | ↑↑ |
| Sensitivity to RAS blockade | (−) | (+) | ? | (+) |
| Reference # | [33] | [32, 34, 39, 40] | [35] | [36, 37, 41] |
*Vs. diabetic wild-type (DM WT) mice.