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. 2014 Sep 17;3(9):e136. doi: 10.1038/psp.2014.34

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Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Exposure–response relationship for bleeding (including major bleeding, minor bleeding, potentially significant nonovert bleeding, clinically relevant nonmajor bleeding, and fatal bleeding) in TKR (ADVANCE 2, left panel) and THR (ADVANCE 3, right panel) subjects. Solid line represents the median bleeding probability and dotted lines represent the 95% confidence intervals. Observed bleeding (%) in “subjects w/PK” indicates the subjects in the E-R analysis dataset, whereas “all subjects” indicates the observed rate from the overall ADVANCE 2 and 3 populations, respectively. AUC_ss, area under plasma concentration–time curve at steady state; b.i.d., twice daily; TDD, total daily dose; THR, total hip replacement; TKR, total knee replacement.