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. 2014 Sep 3;3(9):e133. doi: 10.1038/psp.2014.30

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Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Model simulated ADA responses under physiologically plausible range of parameter values. (a,c,e,g) Model simulated kinetic profiles for ADA.(b,d,f,h) Cumulative amount of ADA during the simulation time against parameters of interest. The parameters of interest are: panels a and b, initial naïve T-cell number; panels c and d, initial naïve B-cell number; panels e and f, affinity of T-epitope for MHC-II; panels g and h, antigen dose. The numbers 1 to 10 on the left panels stand for 10 different parameter conditions, from low to high amounts. More details can be found in the Methods section. ADA, antidrug antibody.