Fig. 3.

(A) Mean (±S.E.M.) responses per session on the EtOH lever by P rats given i.p. saline (n = 4/time point) or 1 or 10 mg/kg cocaine (n = 7–8/dose/time point) immediately, 30 minute or 4 hour prior to only the 1^st EtOH relapse session. Upper Panel: (*) indicates that rats administered saline responded significantly (p < 0.05) more on the EtOH lever during the 1^st relapse session compared to baseline levels. (#) indicates that 10 mg/kg dose cocaine decreased EtOH lever responding during the 1^st relapse session compared to the saline group or baseline values. Middle Panel: (*) indicates that rats administered saline, 1 mg/kg and 10 mg/kg cocaine responded significantly (p < 0.05) more on the EtOH lever during the 1^st relapse session compared to baseline levels. (#) indicates that responses by the 10 mg/kg cocaine group during the 1^st relapse session were higher than the saline group (p<0.05). Lower Panel: (*) indicates that rats administered saline, 1.0 and 10 mg/kg of cocaine responded significantly (p < 0.05) more on the EtOH lever during the 1^st EtOH relapse session compared to baseline levels. (#) indicates that responding by the 10 mg/kg cocaine group was significantly more during the 1^st relapse session compared to the saline and 1 mg/kg groups (p<0.05), and responding by the 1 mg/kg cocaine group was higher than the saline group. (B) Mean (±S.E.M.) responses per session on the water lever by P rats given i.p. saline (n = 4/time point) or 1 or 10 mg/kg cocaine (n = 7–8/dose/time point) immediately, 30 minute or 4 hour prior to only the 1^st water relapse session. Lower Panel: (*) indicates that rats administered 1 or 10 mg/kg cocaine 4 hours prior to the session responded significantly (p < 0.05) less on the EtOH lever compared to saline.