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. 2014 Oct 12;2014:692793. doi: 10.1155/2014/692793

Table 4.

Dissolution parameters of plain drug, marketed product, and LSC formulation.

Dissolution parameter 0.1 N HCl ABS (0.5% SLS) PBS (0.5% SLS)
PD MT F1 PD MT F1 PD MT F1
Q 15 min (%) 70.41 ± 2.54 25.93 ± 4.60 96.08 ± 2.53 57.35 ± 1.18 69.28 ± 4.46 102.12 ± 3.54 45.01 ± 7.73 75.33 ± 2.02 96.31 ± 1.24
Q 30 min (%) 71.82 ± 3.32 46.30 ± 4.38 103.6 ± 1.61 64.85 ± 3.72 78.15 ± 5.07 102.12 ± 3.54 65.62 ± 2.66 82.90 ± 2.89 106.5 ± 6.2
DE30 (%) 9.44 ± 0.44 1.96 ± 0.74 100 ± 1.38 9.97 ± 0.12 40.61 ± 0.83 100 ± 1.14 6.93 ± 0.69 25.57 ± 0.02 100 ± 1.66
MDT (min) 32.02 ± 0.20 62.97 ± 2.86 4.78 ± 0.17 22.03 ± 1.82 13.65 ± 1.62 3.35 ± 0.6 38.13 ± 2.36 72.51 ± 4.44 4.36 ± 1.86

PD: plain drug.

MT: marketed tablet.

F1: optimized LSC formulation (refer Table 1 for composition).