Table 2.
Estimated cox models + (estimated means and standard errors of log hazards ratios, p-values of testing covariate effects, and p-values of testing the proportional hazards assumptions) by cohort and gender
| |
Charleston |
Framingham original |
Framingham offspring |
NHANES I |
NHANES II |
NHIS |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female 580/1,102 | Male 549/850 | Female 1,371/2,521 | Male 1,393/2,005 | Female 145/2,270 | Male 299/2,174 | Female 1,966/7,826 | Male 2,271/5,327 | Female 874/4,815 | M 1,236/4,254 | Female 6,043/7,4410 | M 5,525/5,3910 | |
| Age (5 years) |
0.47 (0.02) |
0.40 (0.02) |
0.52 (0.02) |
0.48 (0.02) |
0.52 (0.05) |
0.55 (0.03) |
0.48 (0.01) |
0.46 (0.01) |
0.49 (0.02) |
0.49 (0.02) |
0.45 (0.01) |
0.42 (0.01) |
| <0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
| 0.48 |
0.60 |
0.01 |
0.40 |
0.81 |
0.53 |
0.04 |
0.004 |
0.46 |
0.03 |
0.02 |
0.001 |
|
| Non-Smoker |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Smoker |
0.37 (0.09) |
0.61 (0.10) |
0.33 (0.06) |
0.34 (0.06) |
1.01 (0.18) |
0.68 (0.12) |
0.43 (0.06) |
0.42 (0.05) |
0.65 (0.08) |
0.70 (0.07) |
0.65 (0.03) |
0.58 (0.03) |
| <0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
| 0.73 |
0.75 |
0.45 |
0.05 |
0.23 |
0.42 |
0.30 |
0.005 |
0.08 |
0.03 |
0.69 |
0.10 |
|
| White |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Black |
0.41 (0.09) |
0.20 (0.09) |
NA |
NA |
NA |
NA |
0.32 (0.06) |
0.18 (0.06) |
0.09 (0.11) |
−0.09 (0.09) |
0.23 (0.04) |
0.30 (0.04) |
| <0.001 |
0.02 |
|
|
|
|
<0.001 |
0.002 |
0.42 |
0.31 |
<0.001 |
<0.001 |
|
| 0.89 |
0.56 |
|
|
|
|
0.37 |
0.79 |
0.09 |
0.68 |
0.85 |
0.76 |
|
| Hispanic |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
−0.20 (0.13) 0.13 0.78 |
−0.23 (0.12) 0.06 0.43 |
| LBMIc* |
−1.89 (0.53) |
0.49 (0.69) |
−2.04 (0.42) |
−1.79 (0.54) |
1.79 (1.21) |
4.72 (11.29) |
−0.45 (0.28) |
−0.58 (0.33) |
0.11 (0.43) |
0.49 (0.51) |
−0.24 (0.16) |
1.00 (0.21) |
| <0.001 |
0.48 |
<0.001 |
0.001 |
0.14 |
0.68 |
0.11 |
0.08 |
0.80 |
0.34 |
0.14 |
<0.001 |
|
| 0.23 |
0.60 |
0.07 |
0.04 |
0.41 |
0.71 |
0.23 |
<0.001 |
0.58 |
0.85 |
0.61 |
0.001 |
|
| LBMIc2** |
1.33 (4.74) |
16.31 (7.67) |
21.79 (4.17) |
20.71 (5.64) |
25.74 (11.84) |
30.46 (12.35) |
17.45 (2.24) |
28.28 (2.95) |
18.55 (3.41) |
4.94 (3.83) |
19.97 (1.18) |
22.19 (1.56) |
| 0.78 |
0.03 |
<0.001 |
<0.001 |
0.03 |
0.01 |
<0.001 |
<0.001 |
<0.001 |
0.20 |
<0.001 |
<0.001 |
|
| 0.35 | 0.87 | 0.44 | 0.75 | 0.10 | 0.08 | 0.81 | 0.22 | 0.002 | 0.44 | 0.61 | 0.48 | |
+These are Cox regression models with all the covariates in the table included simultaneously.
*LBMIc: LBMI centered by its mean of all individuals included in each model and multiplied by 10. The variable was scaled (multiplied by 10) so that the coefficients are not too large.
**LBMIc2: the square term of LBMIc.
In each cell, the value at the bottom row is the p-value of testing the proportional hazards assumption and any p-value <0.05 was considered significant and 0.05 < =p-value <0.1 was considered a borderline case (with three rows).