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. 2014 Mar 17;22(2):246–255. doi: 10.1111/wrr.12154

Figure 6.

Figure 6

The concentration of cytokines and growth factors in the BLCC conditioned medium differs from Fibroblast matrix or Epithelium only conditioned media throughout the manufacturing process. IL-6 (A), IL-8 (B), and VEGF (C) concentrations in conditioned media were quantified at each time point in the manufacturing process. Each construct produced significantly different levels of IL6 and IL8 compared with the other two constructs within the same time point (p < 0.05, Kruskall–Wallis, n = 4), except at Day 6, in which BLCC and Fibroblast matrix were not different. For VEGF, each construct produced significantly different levels of VEGF compared with the other two constructs at Days 15, 17, and 20 (p < 0.05, ANOVA, n = 4). *Indicates different from Fibroblast matrix and Epithelium only within same time point (p < 0.05). †Indicates different from Fibroblast matrix within same time point (p < 0.05). Data are presented as mean ± SD, n = 4 constructs per time point. BLCC, bilayered living cellular construct; IL, interleukin; VEGF, vascular endothelial growth factor.