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. 2014 Mar 17;22(2):246–255. doi: 10.1111/wrr.12154

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© 2014 The Authors. Wound Repair and Regeneration published by Wiley Periodicals, Inc. on behalf of Wound Healing Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Growth factor concentrations produced in conditioned media at Day 20 vary by construct type for IGF-1 (A) but are not different for BMP-2 (B). The Fibroblast matrix produced high levels of IGF-1, which was diminished when combined with keratinocytes in the BLCC. BMP-2 production did not change based on the cell types present in the constructs. For nonnormally distributed IGF-1 data, Kruskal–Wallis with pairwise comparisons was performed. For normally distributed BMP-2 data which exhibited non-homogeneity of variances, ANOVA with Welch correction factor was performed. *Indicates different from Fibroblast matrix and Epithelium only within same time point (p < 0.05). †Indicates different from Fibroblast matrix within same time point (p < 0.05). Data are presented as mean ± SD, n = 4. BLCC, bilayered living cellular construct; IGF-1, insulin-like growth factor-1; BMP-2, bone morphogenetic protein-2.