Figure 1.

FADD deletion decreases liver damage and inflammation and prevents HCC in NEMO^LPC-KO mice. (a) Serum ALT levels in 8-week-old mice. (b) Liver sections of 8-week-old mice stained with Masson's Trichrome and for cleaved caspase-3, Ki-67, F4/80 and Lys6G/Gr1. Arrows indicate GR1-positive cells (granulocytes) (c) qRT-PCR analysis of mRNA isolated from total liver tissue of 8-week-old mice (n=5 per genotype, expression normalized to Tbp). (d) Serum ALT levels from 1-year-old mice. (e) Representative macroscopic picture and H&E-stained liver section of 1-year-old NEMO^LPC-KO/FADD^LPC-KO mice