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. 2014 Jul 11;21(11):1805–1814. doi: 10.1038/cdd.2014.95

Figure 1.

Figure 1

WWOX deficiency is associated with a cell-autonomous increase in glucose uptake. (a) Glucose level was measured in the serum of Wwox WT and KO mice (n=5 per each genotype). Error bars indicate ±S.E.M. (b) Insulin level was measured in the serum of Wwox WT and KO mice (WT, n=9; KO, n=13). Error bars indicate ±S.E.M. (c) Wwox WT and KO MEFs (n=5 per each genotype) were grown in the presence of the fluorescent glucose analog NBDG for 1 h, and glucose uptake was then quantified using flow cytometry (FACS). Error bars indicate ±S.E.M. (d) Wwox KO MEFs were infected with empty vector (EV) or WWOX-expressing lentivirus. Infected cells were selected by puromycin, and following expansion, cells (n=3; WWOX, n=3) were assayed for glucose uptake following 1-h incubation with NBDG. Error bars indicate ±S.E.M.