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CRE-ERT2-mediated deletion of Prkar1a caused an increase in PKA activation and apoptosis in MEFs. (a) Western blot and (b) qPCR analyses to determine the impact of Prkar1a deletion on PKA activation and expression of Bim. p-PKA-sub is a substrate of PKA. Nur77 is a gene that is activated by PKA. (c and d) Clonogenic survival of MEFs after Prkar1a deletion. Error bars±S.E.M., n=3, two-tailed t-tests. ***P=1.2E−4; *P=0.02, #P=0.0016
