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Combined deletion of Bim and Prkar1a promoted tumour growth by MEFs in immunodeficient BALB/c-nude mice with 100% penetrance. (a) Bim−/−;Prkar1a −/− MEF grow as tumours in immunodeficient BALB/c-nude mice. Arrowheads indicate the site where MEFs were injected. (b) Summary of tumour growth by injected MEFs of the indicated genotypes. (c and d) Analysis of γ-H2AX levels in MEF-derived tumours as determined by western blotting or FACS. Error bars±S.D., n=12 for each genotype
