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. Author manuscript; available in PMC: 2014 Oct 28.
Published in final edited form as: Proc IEEE Int Symp Biomed Imaging. 2011 March-April;2011:2095–2098. doi: 10.1109/ISBI.2011.5872825

Table 1.

Summary of qualitative changes in multi-parametric MRI imaging parameters pre- and post-RT, and the corresponding quantitative features used by CADOnc© to characterize each protocol.

Pre-RT appearance Post-RT appearance CADOnc© features
T2w low T2w signal intensity
in peripheral zone
Hypo-intense regions, smooth texture
No change in residual CaP regions
1st order statistics, Kirsch/Sobel (gradients)
2nd order co-occurrence (Haralick)
MRS elevated levels of Ach
reduced levels of Acit
Nearly absent Acit, polyamines in benign, CaP
Residual CaP has elevated Ach, Acr
[Ach, Acr, Acit,
Ach+cr/Acit, Ach/Acr]
DWI significantly low ADC
compared to benign
Increased ADC in entire prostate compared to pre-RT
Residual CaP lower ADC compared to benign areas
Raw ADC values, gradients
1st and 2nd order statistics